Indole-3-carbinol (I-3-C) is a phytonutrient that is present in vegetables of the Brassicarcaceae family such as broccoli and cabbage. I-3-C is one of the key ingredients found in these health promoting foods. Although converted to GPD (3,3'-diindolylmethane) in the body, many studies have had phenomenal success using I-3-C as a supplement.
Studies have shown that by altering the balance of metabolic enzymes that process estrogen, I-3-C reduces the formation of "bad" estrogen and increases the formation of "good" estrogen. Studies targeting women taking I-3-C have demonstrated a favorable change in estrogen metabolism and that I-3-C has a protective effect against estrogen dominance in women. Estrogen dominance has been linked to fibroids, breast tenderness, premenstrual syndrome, endometriosis and health problems in women.
Women who are concerned with estrogen metabolism, who have a family history, or increased risk, or have a higher ratio of bad to good estrogens can benefit from the addition of I-3-C. I-3-C may also be a beneficial supplement for those who want to reap some of the benefits of cruciferous vegetables like broccoli but have difficulty eating it raw.
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